HCID 13740041、化合物 → (1-Chlorocyclopropyl)(4-fluorophenyl)methanone
反応式
[Cl:1][CH:2]([C:6]([C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)=[O:7])[CH2:3][CH2:4]Cl>C(O)(C)(C)C>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]([C:2]2([Cl:1])[CH2:4][CH2:3]2)=[O:7])=[CH:9][CH:10]=1参加物
3
反応条件
- 温度
- 40 °C
実験手順
233 g (0.99 mol) of 4-fluorophenyl 1,3-dichloropropyl ketone are dissolved in 300 ml of tert.-butanol and 135 g of potassium tert.-butylate are added in portions. The mixture is substantially stirred at 40° C. for 2 hours and concentrated in vacuo. The residue is taken up in methylene chloride and water. The organic phase is seperated off, dried over sodium sulphate and concentrated in vacuo. The residue is distilled under a high vacuum. 145 g (74% of theory) of 1-(4-fluorobenzoyl)-1-chloro-cyclopropane of boiling point 73° C./0.1 mbar are obtained.
後処理
- concentrationconcentrated in vacuo
- customThe organic phase is seperated off
- dry with materialdried over sodium sulphate
- concentrationconcentrated in vacuo
- distillationThe residue is distilled under a high vacuum
出典と根拠
- ORDレコード
- ord-bc79fda6a8934fb5a58439b21f02e166
- 出典データセット
- uspto-grants-1989_07
- 特許番号
- US04847279
反応ノート
読み込み中…