Sodium Iodide → 3-Iodomethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione

HRID 231560

反応式

HRID 231560 の反応式
Cl[CH2:2][CH:3]1[CH2:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[C:4]1=[O:16].[I-:17].[Na+]>CC(C)=O>[I:17][CH2:2][CH:3]1[CH2:7][C:6](=[O:8])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[C:4]1=[O:16]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 200334793-Chloromethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione

生成物 1

HCID 200335443-Iodomethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione収率 92%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

A solution of 15.2 g (0.06 moles) 3-chloromethyl-1-(4-fluorophenyl)-pyrrolidine-2,5-dione (according to Example 1) and 10.7 g (0.066 moles) sodium iodide in acetone were refluxed for 8 hours in acetone. The precipitated sodium chloride was then filtered off, and the filtrate was concentrated, extracted with chloroform and the extract once more concentrated. The desired product was obtained in a yield of 92%. Melting point: 156° C.

後処理

  1. filtrationThe precipitated sodium chloride was then filtered off
  2. concentrationthe filtrate was concentrated
  3. extractionextracted with chloroform
  4. extractionthe extract once more
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-24dd3ef3458d4214aa2f8d4a0a3fc612
出典データセット
uspto-grants-1989_07
特許番号
US04847285

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