Sodium Hydroxide → 1-Benzylcyclobutane-1-carboxylic acid

HRID 231608ノート

反応式

HRID 231608 の反応式
[C:1]1([CH2:7][C:8]2([C:12]([O:14]CC)=[O:13])[CH2:11][CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C.O>[C:1]1([CH2:7][C:8]2([C:12]([OH:14])=[O:13])[CH2:11][CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 15632049Ethyl 1-benzylcyclobutanecarboxylate

生成物 1

HCID 156705181-Benzylcyclobutane-1-carboxylic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

A mixture of ethyl 1-phenylmethylcyclobutanecarboxylate (4.16 g, 19.1 mmol), sodium hydroxide (1.2 g, 30 mmol) in ethanol (95%, 20 ml) and water (5 ml) was stirred at room temperature for 60 hours. The reaction mixture was poured into cold water and extracted with diethyl ether. The aqueous phase was separated, acidified with HCl (2N, 35 ml) and extracted with diethyl ether. The latter extract was washed with water, dried, filtered and evaporated to afford the desired product as a pale yellow oil: NMR (CDCl3) δ=1.7~2.6 (6H, m), 3.10 (2H, s), 7.22 (5H, s).

後処理

  1. extractionextracted with diethyl ether
  2. customThe aqueous phase was separated
  3. extractionextracted with diethyl ether
  4. extractionThe latter extract
  5. washwas washed with water
  6. customdried
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-e4e4564fde5e436f815be29d73e6aca3
出典データセット
uspto-grants-1989_07
特許番号
US04847306

反応ノート

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