Imidazole → Pyrimidine, 2,4-di-1H-imidazol-1-yl-

HRID 231789ノート

反応式

HRID 231789 の反応式
Cl[C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH:9]1[CH:13]=[CH:12][N:11]=[CH:10]1>O1CCCC1>[N:9]1([C:2]2[N:7]=[C:6]([N:9]3[CH:13]=[CH:12][N:11]=[CH:10]3)[CH:5]=[CH:4][N:3]=2)[CH:13]=[CH:12][N:11]=[CH:10]1

参加物

4

反応物 2

HCID 795ImidazoleHCID 775312,4-Dichloropyrimidine

生成物 1

HCID 10751012Pyrimidine, 2,4-di-1H-imidazol-1-yl-収率 76.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In anhydrous tetrahydrofuran, 149 mg of 2,4-dichloropyrimidine was substituted with 136 mg of imidazole. The reaction mixture was treated according to the procedure of Example 1 to yield 163 mg of 2,4-bis(1-imidazolyl)pyrimidine, recrystallized from a mixture of n-hexane and ethyl acetate, the compound had a melting point of 131°-132° C.

後処理

  1. additionThe reaction mixture was treated

出典と根拠

ORDレコード
ord-042e58c582b441edafece2dd51d7938a
出典データセット
uspto-grants-1989_07
特許番号
US04849424

反応ノート

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