Imidazole → 4-Chloro-6-(1H-imidazol-1-yl)pyrimidine
反応式
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH:13]=[CH:12][N:11]=[CH:10]1>O1CCCC1>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)[CH:7]=1参加物
4
実験手順
In anhydrous tetrahydrofuran, 298 mg of 4,6-dichloro-pyrimidine was substituted with 136 mg of imidazole. The reaction mixture was treated according to the procedure of Example 5 to yield 283 mg of the 6-chloro-4-(1-imidazolyl)pyrimidine, recrystallized from a mixture of n-hexane and ethyl acetate, having a melting point of 131.5°-132° C.
後処理
- additionThe reaction mixture was treated
出典と根拠
- ORDレコード
- ord-2646394a7cfe44e19a0b15fe7bac536d
- 出典データセット
- uspto-grants-1989_07
- 特許番号
- US04849424
反応ノート
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