Imidazole → 2-chloro-4-(1H-imidazol-1-yl)pyrimidine
反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH:9]1[CH:13]=[CH:12][N:11]=[CH:10]1>O1CCCC1>[Cl:1][C:2]1[N:7]=[C:6]([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)[CH:5]=[CH:4][N:3]=1参加物
4
実験手順
In anhydrous tetrahydrofuran, 680 mg of 2,4-dichloropyrimidine was substituted with 680 mg of imidazole. The reaction mixture was then treated according to the procedure of Example 5 to yield 840 mg of the 2-chloro-4-(1-imidazolyl)pyrimidine, recrystallized from a mixture of n-hexane and ethyl acetate, having a melting point of 127.5°-128° C.
後処理
- additionThe reaction mixture was then treated
出典と根拠
- ORDレコード
- ord-b4444250b0d64839955316a3506c0fd3
- 出典データセット
- uspto-grants-1989_07
- 特許番号
- US04849424
反応ノート
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