Methanol → Pyrimidine, 4-(1H-imidazol-1-yl)-6-methoxy-
反応式
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)[CH:3]=1.[Na].[CH3:14][OH:15]>>[N:8]1([C:4]2[CH:3]=[C:2]([O:15][CH3:14])[N:7]=[CH:6][N:5]=2)[CH:12]=[CH:11][N:10]=[CH:9]1参加物
4
実験手順
Following the procedure of Example 15, 180 mg of 6-chloro-4-(1-imidazolyl)pyrimidine was reacted with 23 mg of sodium metal and 2 ml of anhydrous methanol to yield 136 mg 4-(1-imidazolyl)-6-methoxypyrimidine, having a melting point of 152°-153° C., recrystallized from a mixture of n-hexane and ethyl acetate.
出典と根拠
- ORDレコード
- ord-0256f64bed2545eea9ed40cf1037b7e3
- 出典データセット
- uspto-grants-1989_07
- 特許番号
- US04849424
反応ノート
読み込み中…