Imidazole → 2-Imidazolyl-4,6-dichloropyrimidine

HRID 23183

反応式

HRID 23183 の反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Cl[C:7]1[C:8]([Cl:14])=[N:9][C:10](Cl)=[N:11][CH:12]=1.C(N(CC)CC)C.[Cl-:22].[NH4+]>C1COCC1>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:10]1[N:11]=[C:12]([Cl:22])[CH:7]=[C:8]([Cl:14])[N:9]=1

参加物

6

反応物 4

HCID 795ImidazoleHCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 2372592,4,5-Trichloropyrimidine

生成物 1

HCID 221700012-Imidazolyl-4,6-dichloropyrimidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

One equivalent of imidazole is added in one portion to a solution of one equivalent of trichloropyrimidine and 1.5 equivs of triethylamine in THF. After reaction is complete, the reaction mixture is poured into saturated, aqueous ammonium chloride and extracted three times with ethyl acetate. The combined organic layers are washed with brine and dried. The reaction mixture is filtered and all volatiles removed under reduced pressure. The product, 2-imidazolyl-4,6-dichloropyrimidine (the compound of formula (VIIIa)) is isolated by flash chromatography (20% ethyl acetate in hexane) as an off-white solid.

後処理

  1. customAfter reaction
  2. extractionextracted three times with ethyl acetate
  3. washThe combined organic layers are washed with brine
  4. customdried
  5. filtrationThe reaction mixture is filtered
  6. customall volatiles removed under reduced pressure

出典と根拠

ORDレコード
ord-e92879e3496d4112afd23c6d1dc6781a
出典データセット
uspto-grants-2005_02
特許番号
US06849739B2

関連ノート

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