3-(2,2-Dibromoethenyl)-2,2-dimethylcyclopropane-1-carbonyl chloride → HCID 20032126、化合物

HRID 231840

反応式

HRID 231840 の反応式
C(N1C2[C:7](=[CH:8][CH:9]=CC=2)[C:6]([CH:13]([OH:15])[CH3:14])=[C:5]1[C:16](F)(F)F)C#C.[Br:20][C:21]([Br:31])=[CH:22][CH:23]1[CH:25]([C:26](Cl)=[O:27])[C:24]1(C)C>N1C=CC=CC=1>[CH3:16][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH:22]([O:15][CH:13]([CH3:6])[CH3:14])([CH3:23])[CH3:21].[Br:31][C:21]([Br:20])=[CH:22][CH:23]1[CH:25]([C:26]([O-:27])=[O:15])[CH2:24]1

参加物

5

反応物 2

HCID 129405823-(2,2-Dibromoethenyl)-2,2-dimethylcyclopropane-1-carbonyl chlorideHCID 88619781(RS) [1-(2-propynyl)-2-trifluoromethyl-(1H)-indol-3-yl]-ethanol

生成物 2

HCID 20032126HCID 20032126、化合物HCID 21881879Diisopropylether hexane

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

0.82 g of 1 (RS) [1-(2-propynyl)-2-trifluoromethyl-(1H)-indol-3-yl]-ethanol and 20 ml of 3-(2,2-dibromoethenyl)-2,2-dimethyl-cyclopropane-carboxylic acid chloride were mixed together at ambient temperature under an inert atmosphere, and 0.3 ml of pyridine were added. After stirring for 18 hours, the solvents were evaporated under reduced pressure to obtain 3.15 g of crude product which was purified by chromatography over silica (eluent: hexane-ethyl acetate 9-1 then hexane-isopropyl ether 9-1) to obtain 1(RS) [1-(2-propynyl)-2-trifluoromethyl-)1H)-indol-3-yl]-ethyl 1R,cis 2,2-dimethyl [3-(2,2-dibromoethenyl)-cyclopropane-carboxylate with a specific rotation of [α]D20 =-30.5°±1.6° (c=0.6% in toluene).

後処理

  1. additionwere added
  2. customthe solvents were evaporated under reduced pressure
  3. customto obtain 3.15 g of crude product which
  4. customwas purified by chromatography over silica (eluent

出典と根拠

ORDレコード
ord-0eb7d25190ac4e4fb8a88d52d2ed4394
出典データセット
uspto-grants-1989_07
特許番号
US04849443

関連ノート

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