L-Proline, ethyl ester → HCID 131716003、化合物

HRID 231942

反応式

HRID 231942 の反応式
[F:1][C:2]([F:45])([F:44])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][C@H:10]([O:23][P:24]([CH:28]([NH:33]C(OCC1C=CC=CC=1)=O)[CH2:29][CH2:30][CH2:31][CH3:32])([O:26][CH3:27])=[O:25])[C:11]([N:13]1[CH2:22][CH2:21][CH2:20][C@H:14]1[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:12])=[O:4].N1CCC[C@H]1C(OCC)=O>CO.[OH-].[OH-].[Pd+2]>[F:44][C:2]([F:1])([F:45])[C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][C@H:10]([O:23][P:24]([CH:28]([NH2:33])[CH2:29][CH2:30][CH2:31][CH3:32])([O:26][CH3:27])=[O:25])[C:11]([N:13]1[CH2:22][CH2:21][CH2:20][C@H:14]1[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:12])=[O:4]

参加物

5

反応物 2

HCID 79888L-Proline, ethyl esterHCID 1317160041-[(S)-6-[(Trifluoroacetyl)amino]-2-[[[1-[[(phenylmethoxy)carbonyl]amino]pentyl]methoxyphosphinyl]oxy]-1-oxohexyl]-L-proline, ethyl ester

生成物 1

HCID 131716003HCID 131716003、化合物

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

The ethyl ester product from part (e) (1.75 g., 2.63 mmole) is dissolved in methanol (75 ml.) at room temperature under argon. The solution is hydrogenated with 20% palladium hydroxide on carbon catalyst (300 mg.) at room temperature and atmospheric pressure for 3 hours. The reaction is filtered through Celite to remove the catalyst, and the volatiles are evaporated to give 1.7 g. of 1-(S)-6-[(Trifluoroacetyl)amino]-2-[[[(1-amino)pentyl]methoxyphosphinyl]oxy]-1-oxohexyl]-L-proline, ethyl ester.

後処理

  1. filtrationThe reaction is filtered through Celite
  2. customto remove the catalyst
  3. customthe volatiles are evaporated
  4. customto give 1.7 g

出典と根拠

ORDレコード
ord-27c87647c46d4e8fbbafb6437f0685fc
出典データセット
uspto-grants-1989_07
特許番号
US04849414

関連ノート

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