Hydrochloric Acid → Benzoyl fluoride, 2,3,4-trichloro-5-fluoro-

反応式

[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([Cl:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[FH:14].Cl>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([Cl:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([F:14])=[O:5]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 14917Hydrofluoric Acid

HCID 141498692,3,4-Trichloro-5-fluorobenzoyl chloride

生成物 1

HCID 14149871Benzoyl fluoride, 2,3,4-trichloro-5-fluoro-

実験手順

480 g (1.83 mols) of 2,3,4-trichloro-5-fluorobenzoyl chloride are introduced, with 240 g (12 mols) of hydrogen fluoride, at -5° to 0° C. into a stirred autoclave fitted with a pressure-control valve, the apparatus is pressure-sealed and warmed to 70° C. in steps, corresponding to the evolution of HCl. The hydrogen chloride produced is continuously released at 4-5 bar. When the evolution of HCl is complete, the mixture is cooled, the excess pressure is released and the reaction mixture is fractionated.