Sodium hydride → 3-(Pyrazol-1-yloxy)-propylphthalimide

反応式

[OH:1][N:2]1[CH:6]=[CH:5][CH:4]=[N:3]1.[H-].[Na+].Br[CH2:10][CH2:11][CH2:12][C:13]1[CH:23]=[CH:22][CH:21]=[C:15]2[C:16]([NH:18][C:19](=[O:20])[C:14]=12)=[O:17]>C1(C)C(C)=CC=CC=1>[N:2]1([O:1][CH2:10][CH2:11][CH2:12][C:13]2[CH:23]=[CH:22][CH:21]=[C:15]3[C:16]([NH:18][C:19](=[O:20])[C:14]=23)=[O:17])[CH:6]=[CH:5][CH:4]=[N:3]1

参加物

実験手順

26 g of 1-hydroxypyrazole are added to a suspension of 10 g of sodium hydride (80 percent strength in oil) in 500 ml of xylene. The mixture is stirred for 1 hour, after which 84 g of 3-bromopropylphthalimide are added and the mixture is refluxed for 2 hours. After cooling, the mixture is filtered, the filtrate is evaporated down, the crystalline residue is suspended in diethyl ether and the product is filtered off under suction. 85 g of the title compound of melting point 116°-118° C. are obtained.