Pyridine → 3-(Acetyloxy)-2,2-dimethylpropanoic acid

Acetyl chloride (4.52, 58.2 mmol) was added dropwise to a cold (0° C.) pyridine solution (10 ml) of 2,2-dimethyl-3-hydroxypropionic acid (5.5 g, 46.5 mmol) and 4-DMAP (0.57 g, 4.65 mmol). After stirring overnight at ambient temperature, the reaction was poured into ether (200 ml). This mixture was washed with 10% HCl (2×20 ml), and saturated brine (2×25 ml) and the resulting ethereal solution was dried (MgSO4). Evaporation gave the title compound as a pale yellow solid which was used in the next step without further purification. NMR (CDCl3) δ 4.13 (2 H, s), 2.08 (3 H, s), 1.26 (6 H, s).

1. washThis mixture was washed with 10% HCl (2×20 ml), and saturated brine (2×25 ml)
2. dry with materialthe resulting ethereal solution was dried (MgSO4)
3. customEvaporation

ORDレコード

ord-a870a0c1965147ce963c177be784b19c

出典データセット

uspto-grants-1989_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04851436