Tetrahydrofuran → N-(5-{6-Chloro-5-[3-(2,4-difluorophenyl)ureido]-pyridin-3-yl}-4-methyl-1,3-thiazol-2-yl)acetamide

反応式

[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[F:1][c:2]1[c:3]([N:9]=[C:10]=[O:11])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[NH2:12][c:13]1[cH:14][c:15](-[c:20]2[c:21]([CH3:29])[n:22][c:23]([NH:25][C:26]([CH3:27])=[O:28])[s:24]2)[cH:16][n:17][c:18]1[Cl:19]>>[F:1][c:2]1[c:3]([NH:9][C:10](=[O:11])[NH:12][c:13]2[cH:14][c:15](-[c:20]3[c:21]([CH3:29])[n:22][c:23]([NH:25][C:26]([CH3:27])=[O:28])[s:24]3)[cH:16][n:17][c:18]2[Cl:19])[cH:4][cH:5][c:6]([F:8])[cH:7]1

参加物

反応物 3

HCID 8028Tetrahydrofuran

HCID 5932582,4-Difluorophenyl isocyanate

HCID 86244450N-[5-(5-amino-6-chloropyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]acetamide

生成物 1

HCID 86620402N-(5-{6-Chloro-5-[3-(2,4-difluorophenyl)ureido]-pyridin-3-yl}-4-methyl-1,3-thiazol-2-yl)acetamide

出典と根拠

ORDレコード: ord-695b18bc09714405a0f28678a2e94618
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…