Lithium aluminum hydride → HCID 20031070、化合物
反応式
[Li+].[AlH4-].[F:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]3[CH2:15][CH2:16][CH2:17][C:13]=3[C:12]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23](O)=[O:24])=[N:11]2)=[CH:6][CH:5]=1>C1COCC1>[F:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:14]3[CH2:15][CH2:16][CH2:17][C:13]=3[C:12]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24])=[N:11]2)=[CH:8][CH:9]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
Lithium tetrahydridoaluminate (0.345 g, 9.1 mmol) in THF (75 ml) was treated with the compound of Example 31 (1.0 g, 3.1 mmol) and the mixture was heated at 60° C. for 2 hours. Excess reagent was quenched, the mixture filtered and the combined filtrate and ethyl acetate washes were evaporated to a colorless oil (0.76 g). Polar impurities were removed on silica gel (40 g) with 1:1 ethyl acetate-Skelly B eluent to provide title compound (0.42 g) as an oil.