18-Crown-6 → 4-(6-Hydroxyhexyloxy)-4'-nitrobiphenyl

HRID 232186

反応式

HRID 232186 の反応式
[K].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.I[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][OH:25].C1OCCOCCOCCOCCOCCOC1>C1(C)C=CC=CC=1>[OH:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

参加物

6

反応物 4

HCID 2855718-Crown-6HCID 1380784-Hydroxy-4'-nitrobiphenylHCID 5462222Potassium2 回HCID 130890816-Iodo-1-hexanol

生成物 1

HCID 197795694-(6-Hydroxyhexyloxy)-4'-nitrobiphenyl

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To 500 ml of toluene in a one liter round bottom flask, fitted with a condenser and magnetic stirrer, are added 7.6 g (0.03M) of the potassium salt of 4-hydroxy-4'-nitrobiphenyl, 4.9 g (0.035M) of 6-iodo-1-hexanol, and 0.5 g of 18-crown-6ether. The mixture is refluxed for about 20 hours until all of the potassium salt has dissolved and reacted as evidenced by the absence of the blue crystalline solid. The solution is filtered hot, and then cooled to room temperature. After solvent removal, the solid residue is recrystallized from ethanol to yield a purified product, m.p. 117°-119° C.

後処理

  1. dissolutionhas dissolved
  2. customreacted
  3. filtrationThe solution is filtered hot
  4. customAfter solvent removal
  5. customthe solid residue is recrystallized from ethanol
  6. customto yield a purified product, m.p. 117°-119° C.

出典と根拠

ORDレコード
ord-504722cb99994f9ebfc8e18c90c1158c
出典データセット
uspto-grants-1989_07
特許番号
US04851502

関連ノート

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