Thionyl Chloride → HCID 14798665、化合物

HRID 232200ノート

反応式

HRID 232200 の反応式
O=[C:2]([CH2:7][CH2:8][C:9]([O-:11])=[O:10])[C:3]([O:5][CH3:6])=[O:4].S(Cl)([Cl:14])=O>ClCCl.CN(C)C=O>[Cl:14][C:2]1([C:3]([O:5][CH3:6])=[O:4])[CH2:7][CH2:8][C:9](=[O:10])[O:11]1

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 22166434HCID 22166434、化合物

生成物 1

HCID 14798665HCID 14798665、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

In 10 ml of dichloromethane was dissolved 1.0 g of Compound (10). To the solution were added 911 μl of thionyl chloride and one drop of N,N-dimethylformamide. The mixture was stirred at room temperature for 15 hours. The reaction solution was concentrated. The concentrate was subjected to a flash chromatography using silica gel, followed by elution with hexane-ethyl acetate (1:2) to give 985 mg of the subject Compound (13).

後処理

  1. concentrationThe reaction solution was concentrated
  2. washfollowed by elution with hexane-ethyl acetate (1:2)

出典と根拠

ORDレコード
ord-0d105a575c56437eba7cd942398fe09e
出典データセット
uspto-grants-1989_07
特許番号
US04851422

反応ノート

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