Thionyl Chloride → HCID 14049831、化合物

HRID 232202ノート

反応式

HRID 232202 の反応式
O=[C:2]([CH2:16][CH2:17][C:18]([O-:20])=[O:19])[C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)=[O:4].S(Cl)([Cl:23])=O>ClCCCl>[Cl:23][C:2]1([C:3]([O:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([N+:13]([O-:15])=[O:14])=[CH:11][CH:12]=2)=[O:4])[CH2:16][CH2:17][C:18](=[O:19])[O:20]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 221664155-[(4-Nitrophenyl)methoxy]-4,5-dioxopentanoate

生成物 1

HCID 14049831HCID 14049831、化合物

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

In 16 ml of 1,2-dichloroethane was dissolved 0.40 g of the Compound (1) obtained in Example 1. To the solution was added 0.88 ml of thionyl chloride. The mixture was heated for 10 hours under reflux. The solvent was evaporated off, and the residue was subjected to a silica gel column chromatography, followed by elution with hexane-ethyl acetate (3:1) to give 0.36 g of the subject Compound (15) as colorless oil.

後処理

  1. temperatureThe mixture was heated for 10 hours
  2. temperatureunder reflux
  3. customThe solvent was evaporated off
  4. washfollowed by elution with hexane-ethyl acetate (3:1)

出典と根拠

ORDレコード
ord-d0ae1d9eed84417eaaa8d23cb6753991
出典データセット
uspto-grants-1989_07
特許番号
US04851422

反応ノート

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