Morpholine → 4-(Morpholin-4-yl)butan-2-ol

HRID 232254ノート

反応式

HRID 232254 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][CH2:9][CH:10]([OH:12])[CH3:11]>CC#N>[CH3:11][CH:10]([OH:12])[CH2:9][CH2:8][N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 8083MorpholineHCID 124844794-Chlorobutan-2-ol

生成物 1

HCID 145556014-(Morpholin-4-yl)butan-2-ol

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To 100 mL of CH3CN is added morpholine (9.6 g, 0.11 mol) and 4-chloro-2-butanol (11 g, 0.1 mol). Heat the reaction at reflux and monitor the reaction by thin-layer chromatography. Upon completion of the reaction remove the solvent and add saturated aqueous sodium bicarbonate and ether. Separate the layers and dry the organic phase over Na2SO4. Filter off the drying agent and evaporate the solvent in vacuo to obtain the title compound.

後処理

  1. temperatureHeat
  2. customthe reaction
  3. temperatureat reflux
  4. customthe reaction by thin-layer chromatography
  5. customUpon completion of the reaction remove the solvent
  6. additionadd saturated aqueous sodium bicarbonate and ether
  7. customSeparate the layers
  8. dry with materialdry the organic phase over Na2SO4
  9. filtrationFilter off the drying agent
  10. customevaporate the solvent in vacuo

出典と根拠

ORDレコード
ord-c0c0a9d00bd246a3b1f9512ce8148dcb
出典データセット
uspto-grants-1989_07
特許番号
US04851526

反応ノート

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