Hydrochloric Acid → 1,2-Diethyl-4-piperidinone

HRID 232274

反応式

HRID 232274 の反応式
C[Si](C)(C)[O:3][C:4]([CH:6]=[CH2:7])=[CH2:5].[CH2:10]([NH:12][CH2:13][CH2:14][CH3:15])[CH3:11].B(F)(F)F.CCOCC.Cl>C(Cl)Cl>[CH2:10]([N:12]1[CH2:7][CH2:6][C:4](=[O:5])[CH2:3][CH:13]1[CH2:14][CH3:15])[CH3:11]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8000Boron trifluoride etherateHCID 883981-Propanamine, N-ethyl-HCID 5546572-(Trimethylsiloxy)-1,3-butadiene

生成物 1

HCID 200313151,2-Diethyl-4-piperidinone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 100 mL of methylene chloride cooled to 0° C. is added 2-(trimethylsilyloxy)-1,3-butadiene (14.2 g, 0.1 mol), 8.5 g (0.1 mol) of N-ethyl-propanamine, and 14.2 g (0.1 mol) of borontrifluoride etherate. Monitor the reaction by thinlayer chromatography. Upon completion add 1N HCl until gas evolution ceases. Separate the aqueous layer and make it alkaline with 1N NaOH. Extract twice with 100 mL ether and dry over Na2SO4. Filter the drying agent and evaporated the solvent in vacuo to obtain the title compound.

後処理

  1. customMonitor the reaction by thinlayer chromatography
  2. customSeparate the aqueous layer
  3. extractionExtract twice with 100 mL ether
  4. dry with materialdry over Na2SO4
  5. filtrationFilter the drying agent
  6. customevaporated the solvent in vacuo

出典と根拠

ORDレコード
ord-dc7eb3e1a8054954978500e3c6bd556b
出典データセット
uspto-grants-1989_07
特許番号
US04851526

関連ノート

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