Methanol → 4-[[2-(3,4,5-Trimethoxyphenyl)ethyl](methyl)amino]hexan-3-ol

HRID 232280

反応式

HRID 232280 の反応式
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[C:9](OC)[C:8]([O:13][CH3:14])=[C:7]([O:15][CH3:16])[CH:6]=1.[CH2:17]([CH:19]1[CH:21]([CH2:22][CH3:23])[O:20]1)[CH3:18].[CH3:24][OH:25]>>[CH3:24][O:25][C:9]1[CH:10]=[C:5]([CH2:4][CH2:3][N:2]([CH3:1])[CH:21]([CH2:22][CH3:23])[CH:19]([OH:20])[CH2:17][CH3:18])[CH:6]=[C:7]([O:15][CH3:16])[C:8]=1[O:13][CH3:14]

参加物

4

反応物 3

HCID 887MethanolHCID 1382642,3-DiethyloxiraneHCID 138365N-Methylmescaline

生成物 1

HCID 200313814-[[2-(3,4,5-Trimethoxyphenyl)ethyl](methyl)amino]hexan-3-ol

実験手順

Combine 22.5 g (0.1 mol) of N-methyl-3,4,5-trimethoxybenzeneethanamine and 10 g (0.1 mol) of 2,3-diethyloxirane in 150 mL of 90% aqueous methanol. Heat the reaction at 50° C. and follow the progress of the reaction by thin-layer chromatography. At the completion of the reaction remove the solvent in vacuo and chromatograph the residue on silica gel to obtain the title compound.

後処理

  1. temperatureHeat
  2. customthe reaction at 50° C.
  3. customthe progress of the reaction by thin-layer chromatography
  4. customAt the completion of the reaction remove the solvent in vacuo and chromatograph the residue on silica gel

出典と根拠

ORDレコード
ord-9557d6b1d5794e29856206cf104fc55c
出典データセット
uspto-grants-1989_07
特許番号
US04851526

関連ノート

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