N-[2-(4-Methylphenoxy)ethyl]acetamide → N-Ethyl-2-(4-methylphenoxy)ethanamine

HRID 232312

反応式

HRID 232312 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]1[CH:20]=[CH:19][C:11]([O:12][CH2:13][CH2:14][NH:15][C:16](=O)[CH3:17])=[CH:10][CH:9]=1>CCOCC>[CH2:16]([NH:15][CH2:14][CH2:13][O:12][C:11]1[CH:10]=[CH:9][C:8]([CH3:7])=[CH:20][CH:19]=1)[CH3:17]

参加物

4

反応物 2

HCID 538338N-[2-(4-Methylphenoxy)ethyl]acetamideHCID 21226445Aluminium lithium hydride

生成物 1

HCID 20031351N-Ethyl-2-(4-methylphenoxy)ethanamine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a chilled suspension of 0.49 g (013 mol) lithium aluminium hydride in 50 mL anhydrous ether, add 5.0 g (025 mol) N-[2-(4-methylphenoxy)ethyl]acetamide at a rate which maintains the reaction temperature below 10° C. Allow to warm to room temperature and stir at ambient temp. for 24 hrs. After this time, quench the mixture with H2O and filter the salts. Concentrate the filtrate to obtain the title compound.

後処理

  1. customthe reaction temperature below 10° C
  2. customAfter this time, quench the mixture with H2O
  3. filtrationfilter the salts
  4. concentrationConcentrate the filtrate

出典と根拠

ORDレコード
ord-936c3c50aef24950848ed4c0bb4bc33b
出典データセット
uspto-grants-1989_07
特許番号
US04851526

関連ノート

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