2-Chloroethanol → N-Ethyl-N-(2-hydroxyethyl)-N-[2-(4-methylphenoxy)ethyl]-amine

HRID 232313

反応式

HRID 232313 の反応式
Cl[CH2:2][CH2:3][OH:4].[CH2:5]([NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)[CH3:6].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:5]([N:7]([CH2:2][CH2:3][OH:4])[CH2:8][CH2:9][O:10][C:11]1[CH:12]=[CH:13][C:14]([CH3:17])=[CH:15][CH:16]=1)[CH3:6]

参加物

5

反応物 3

HCID 342-ChloroethanolHCID 11430Potassium CarbonateHCID 20031351N-Ethyl-2-(4-methylphenoxy)ethanamine

生成物 1

HCID 20031320N-Ethyl-N-(2-hydroxyethyl)-N-[2-(4-methylphenoxy)ethyl]-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Add 0.90 g (011 mol) 2-chloroethanol to a solution of 2.0 g (0.11 mol) N-ethyl-N-[2-(4-methylphenoxy)ethyl]amine and 1.7 g (012 mol) potassium carbonate in 50 mL methanol. Stir at room temperature for 24 hr. After this time, remove the solvents in vacuo and dissolve the residue in 25 mL water. Adjust the aqueous to pH=8 with 5% sodium bicarbonate solution and extract 3×50 mL methylene chloride. Dry the combined organics over sodium sulfate and evaporate the solvent to obtain the desired product.

後処理

  1. customAfter this time, remove the solvents in vacuo
  2. dissolutiondissolve the residue in 25 mL water
  3. extractionextract 3×50 mL methylene chloride
  4. dry with materialDry the combined organics over sodium sulfate
  5. customevaporate the solvent

出典と根拠

ORDレコード
ord-f2eb8d7c4d324159a69739c911fcf09a
出典データセット
uspto-grants-1989_07
特許番号
US04851526

関連ノート

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