HCID 54104497、化合物 → HCID 18633445、化合物
反応式
[CH2:1]([C:3]1[C:4](=[O:26])[NH:5][C:6](=[O:25])[N:7]([CH:24]=1)[C@@H:8]1[O:23][C@H:12]([CH2:13][N:14](C)[CH2:15]C2C=CC=CC=2)[C@@H:10]([OH:11])[CH2:9]1)[CH3:2]>C(O)C.[Pd]>[CH2:1]([C:3]1[C:4](=[O:26])[NH:5][C:6](=[O:25])[N:7]([CH:24]=1)[C@@H:8]1[O:23][C@H:12]([CH2:13][NH:14][CH3:15])[C@@H:10]([OH:11])[CH2:9]1)[CH3:2]参加物
4
実験手順
1.1 g of 2',5'-dideoxy-5-ethyl-5'-(N-methyl-N-benzylamino)uridine were taken up in 75 ml of ethanol and 1 g of 5% palladium-on-carbon catalyst in 25 ml of ethanol was added under a nitrogen atmosphere. The mixture was hydrogenated at room temperature and under atmospheric pressure. The catalyst was removed by filtration and the filtrate was evaporated to give 0.84 g of 2',5'-dideoxy-5-ethyl-5'-methylaminouridine of melting point 145°-147° C.