Potassium Nitrate → HCID 14834673、化合物

HRID 232644ノート

反応式

HRID 232644 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH3:10].[N+:11]([O-])([O-:13])=[O:12].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4]([F:9])[C:3]=1[CH3:10]

参加物

4

反応物 2

HCID 24434Potassium NitrateHCID 146512521,2,4-Trifluoro-3-methylbenzene

生成物 1

HCID 14834673HCID 14834673、化合物収率 94.9%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

反応条件

温度
0 °C

実験手順

To 2,3,6-trifluorotoluene (55 g) is added conc. sulfuric acid (366 ml) and the mixture is cooled to 0° C. Thereto a solution of potassium nitrate (44 g) in conc. sulfuric acid (120 ml) is added dropwise at below 10° C. and then the mixture is stirred for 15 minutes. The mixture is poured into ice-water, extracted with diethyl ether, and the extract is washed with water and dried. The solvent is distilled off to give 2,3,6-trifluoro-5-nitrotoluene (68.25 g), as yellow oil.

後処理

  1. extractionextracted with diethyl ether
  2. washthe extract is washed with water
  3. customdried
  4. distillationThe solvent is distilled off

出典と根拠

ORDレコード
ord-ce0fde7983b64f6da4939107484cf7bf
出典データセット
uspto-grants-1997_01
特許番号
US05591744

反応ノート

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