p-Toluenesulfonic acid → Ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetate

HRID 232656ノート

反応式

HRID 232656 の反応式
[CH3:1][C:2]1[C:7]([C:8]([CH:10](C(OCC)=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:7]([C:8]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:9])=[C:6]([F:21])[C:5]([F:22])=[C:4]([F:23])[C:3]=1[F:24]

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 53783746Diethyl 6-methyl-2,3,4,5-tetrafluorobenzoylmalonate

生成物 1

HCID 14774100Ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetate収率 70.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To diethyl 6-methyl-2,3,4,5-tetrafluorobenzoyl-malonate (8 g) are added water (20 ml) and p-toluenesulfonic acid (80 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetate (4.5 g).

後処理

  1. temperaturethe mixture is refluxed for 2.5 hours
  2. temperatureAfter cooling
  3. extractionthe resultant is extracted with diethyl ether
  4. dry with materialthe extract is dried over magnesium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-fc1a13fa43534541b6407e093912808b
出典データセット
uspto-grants-1997_01
特許番号
US05591744

反応ノート

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