Perchloric Acid → Allopregnanolone

HRID 232797

反応式

HRID 232797 の反応式
C([O:4][C@@H:5]1[CH2:24][CH2:23][C@@:22]2([CH3:25])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:21]2[CH2:20][CH2:19][C@@:18]2([CH3:26])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:17])[CH3:16])[CH2:6]1)(=O)C.Cl(O)(=O)(=O)=O>CO>[OH:4][C@@H:5]1[CH2:24][CH2:23][C@@:22]2([CH3:25])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:21]2[CH2:20][CH2:19][C@@:18]2([CH3:26])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:17])[CH3:16])[CH2:6]1

参加物

4

反応物 2

HCID 24247Perchloric AcidHCID 53835422Allopregnan-3alpha-ol-20-one acetate

生成物 1

HCID 92786Allopregnanolone収率 107.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3α-acetoxy-5α-pregnan-20-one (4.8 g) in 150 mL of methanol was cooled to 0° C. with an ice bath and 15.0 mL of perchloric acid was added dropwise. After 30 m of stirring, the ice bath was removed and the reaction mixture was left stirring for three days. The reaction mixture was poured into water and extracted with chloroform three times. The chloroform extracts were combined, dried over magnesium sulfate, and the solvent evaporated to give 4.57 g of crude product.

後処理

  1. customthe ice bath was removed
  2. waitthe reaction mixture was left
  3. stirringstirring for three days
  4. additionThe reaction mixture was poured into water
  5. extractionextracted with chloroform three times
  6. dry with materialdried over magnesium sulfate
  7. customthe solvent evaporated

出典と根拠

ORDレコード
ord-d869891b434249c19eacca768a8e4da3
出典データセット
uspto-grants-1997_01
特許番号
US05591733

関連ノート

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