反応式
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][C:15]([CH2:19][O:20][C:21]3[CH:47]=[CH:46][C:24]4[O:25][CH2:26][C:27]5[CH:40]=[C:39]([CH2:41][CH2:42][C:43](=[O:45])[CH3:44])[CH:38]=[CH:37][C:28]=5[CH:29]([O:30]C5CCCCO5)[C:23]=4[CH:22]=3)=[N:16]2)=[CH:11][C:10]=1[F:48].C(O)(=O)C>O1CCOCC1.O>[Cl:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][C:15]([CH2:19][O:20][C:21]3[CH:47]=[CH:46][C:24]4[O:25][CH2:26][C:27]5[CH:40]=[C:39]([CH2:41][CH2:42][C:43](=[O:45])[CH3:44])[CH:38]=[CH:37][C:28]=5[CH:29]([OH:30])[C:23]=4[CH:22]=3)=[N:16]2)=[CH:11][C:10]=1[F:48]参加物
反応物 3
生成物 1
試薬・触媒・溶媒 2
実験手順
0.02 ml of trifluoroacetic acid was added to 0.73 g of 2-(7-chloro-6-fluoroquinolin-2-yl)methoxy-8-(2-acetylethyl)-11-(2-tetrahydropyranyloxy)-6,11-dihydrodibenz[b,e]oxepine obtained in Reference example 74 dissolved in a mixed solution of 5 ml of dioxane and 2 ml of water, the mixture was stirred at room temperature for 15 minutes, 4 ml of acetic acid was added to the mixture and the mixture was stirred for 10 hours. 80 ml of water was added to the reaction mixture and insolubles were removed by filtration. The residue was dissolved in chloroform and the organic layer was washed with water and dried over anhydrous sodium sulfate. After the solvent was removed, the residue was washed with a mixed solution of acetone and ether to obtain 0.41 g of the title compound.
後処理
- customobtained in Reference example 74
- stirringthe mixture was stirred for 10 hours
- customwere removed by filtration
- dissolutionThe residue was dissolved in chloroform
- washthe organic layer was washed with water
- dry with materialdried over anhydrous sodium sulfate
- customAfter the solvent was removed
- washthe residue was washed with a mixed solution of acetone and ether
出典と根拠
- ORDレコード
- ord-ba4536a181754e39a127951667b20ab4
- 出典データセット
- uspto-grants-1997_01
- 特許番号
- US05591752
関連ノート
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