Trifluoroacetic acid → 4'-[(2-Ethyl-4-methyl-6-(3-chloro-5,6,7,8-tetrahydro-imidazo-[1,2-a]pyridin-2-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylic Acid

HRID 233011ノート

反応式

HRID 233011 の反応式
[CH2:1]([C:3]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[C:16]([C:21]([O:23]C(C)(C)C)=[O:22])=[CH:17][CH:18]=[CH:19][CH:20]=3)=[CH:11][CH:10]=2)[C:6]2[CH:28]=[C:29]([C:33]3[N:34]=[C:35]4[CH2:40][CH2:39][CH2:38][CH2:37][N:36]4[C:41]=3[Cl:42])[CH:30]=[C:31]([CH3:32])[C:5]=2[N:4]=1)[CH3:2].FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([C:3]1[N:7]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[C:16]([C:21]([OH:23])=[O:22])=[CH:17][CH:18]=[CH:19][CH:20]=3)=[CH:11][CH:10]=2)[C:6]2[CH:28]=[C:29]([C:33]3[N:34]=[C:35]4[CH2:40][CH2:39][CH2:38][CH2:37][N:36]4[C:41]=3[Cl:42])[CH:30]=[C:31]([CH3:32])[C:5]=2[N:4]=1)[CH3:2]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67708508HCID 67708508、化合物

生成物 1

HCID 199647274'-[(2-Ethyl-4-methyl-6-(3-chloro-5,6,7,8-tetrahydro-imidazo-[1,2-a]pyridin-2-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylic Acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Prepared analogously to Example 208 from tert.butyl 4'-[(2-ethyl-4-methyl-6-(3-chloro-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylate and trifluoroacetic acid in methylene chloride.

出典と根拠

ORDレコード
ord-98a66959900741ae9eec45da04a6414f
出典データセット
uspto-grants-1997_01
特許番号
US05591762

反応ノート

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