Chlorosuccinimide → 6-Acetyl-8-chloropyrrolo[1,2-a]pyrazine
反応式
[C:1]([C:4]1[N:8]2[CH:9]=[CH:10][N:11]=[CH:12][C:7]2=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Cl:13]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[C:1]([C:4]1[N:8]2[CH:9]=[CH:10][N:11]=[CH:12][C:7]2=[C:6]([Cl:13])[CH:5]=1)(=[O:3])[CH3:2]参加物
4
実験手順
0.5 g of 6-acetylpyrrolo[1,2-a]pyrazine prepared in Preparation Example 15 was dissolved in 5 ml of chloroform; and 0.5 g of N-chlorosuccinimide was added threrto. The reaction mixture was refluxed for 2 hours and then concentrated. The residue was chromatographed over silica gel to yield 0.5 g of title compound.
後処理
- temperatureThe reaction mixture was refluxed for 2 hours
- concentrationconcentrated
- customThe residue was chromatographed over silica gel
出典と根拠
- ORDレコード
- ord-1edb7d926dc94e7492f482ea5d86756f
- 出典データセット
- uspto-grants-1997_01
- 特許番号
- US05593984
反応ノート
読み込み中…