Sodium borohydride → 6-(1-Hydroxyethyl)pyrrolo[1,2-a]pyrazine
反応式
[C:1]([C:4]1[N:8]2[CH:9]=[CH:10][N:11]=[CH:12][C:7]2=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>O>[OH:3][CH:1]([C:4]1[N:8]2[CH:9]=[CH:10][N:11]=[CH:12][C:7]2=[CH:6][CH:5]=1)[CH3:2]参加物
4
実験手順
2.0 g of 6-acetylpyrrolo[1,2-a]pyrazine prepared in Preparation Example 15 was added to 30 ml of water; and 0.5 g of sodium borohydride was added thereto. After reacting at 50° C. for 2 hours, the mixture was extracted with ethyl acetate (50 ml×3). The residue was chromatographed over silica gel to yield 1.4 g of 6-(1-hydroxyethyl)pyrrolo[1,2-a]pyrazine.
後処理
- extractionthe mixture was extracted with ethyl acetate (50 ml×3)
- customThe residue was chromatographed over silica gel
出典と根拠
- ORDレコード
- ord-4c9c57ef765b4926a45c20f34eea9f9f
- 出典データセット
- uspto-grants-1997_01
- 特許番号
- US05593984
反応ノート
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