反応式
[NH2:1][CH:2]1[C:14](=[O:15])[N:4]2[C:5]([C:11]([O-:13])=[O:12])=[C:6]([CH2:9]I)[CH2:7][S:8][C@H:3]12.[CH:16]1[C:17]2[N:18]([CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:20][N:21]=1.O>C(#N)C>[NH2:1][CH:2]1[C:14](=[O:15])[N:4]2[C:5]([C:11]([O-:13])=[O:12])=[C:6]([CH2:9][N+:21]3[CH:20]=[CH:19][N:18]4[CH:22]=[CH:23][CH:24]=[C:17]4[CH:16]=3)[CH2:7][S:8][C@H:3]12参加物
5
反応条件
- 温度
- 0 °C
実験手順
2.5 g of 7-amino-3-iodomethyl-3-cephem-4-carboxylate was suspended in 30 ml of acetonitrile; and 2 ml bistrimethyl-silylacetamide was added thereto. To the mixture was added 2 g of pyrrolo[1,2-a]pyrazine prepared in Preparation Example 1. The reaction mixture was reacted at 10° C. for 1 hour and then cooled to 0° C. To this solution was added 0.6 ml of water; and the resulting mixture was filtered and then washed with 30 ml of cold acetonitrile to obtain 2.4 g of light yellow title compound (yield: 93%).
後処理
- customprepared in Preparation Example 1
- customThe reaction mixture was reacted at 10° C. for 1 hour
- filtrationand the resulting mixture was filtered
- washwashed with 30 ml of cold acetonitrile
出典と根拠
- ORDレコード
- ord-59107c343c3e42538453b1fadfae0718
- 出典データセット
- uspto-grants-1997_01
- 特許番号
- US05593984
関連ノート
読み込み中…