Ethanolamine → 1-[(2-Hydroxyethyl)amino]-2-methyl-2-propanol

1-Chloro-2-methyl-2-propanol (135 ml) was added dropwise over 10 min to stirred 2-aminoethanol (400 ml) at 10° C. under nitrogen. The cooling bath was then removed and stirring was continued at room temperature for 48 h. A solution of sodium hydroxide (48.8 g) in methanol (440 ml) was added and the resulting white suspension was stirred for 10 min. The mixture was filtered through a pad of kieselguhr and the filtrate was concentrated under reduced pressure. The residual oil was distilled in vacuo to give 1-[(2-hydroxyethyl)amino]-2-methyl-2-propanol (133 g). b.p. 100°-108° C. (1.5 mm Hg).

1. customThe cooling bath was then removed
2. additionA solution of sodium hydroxide (48.8 g) in methanol (440 ml) was added
3. stirringthe resulting white suspension was stirred for 10 min
4. filtrationThe mixture was filtered through a pad of kieselguhr
5. concentrationthe filtrate was concentrated under reduced pressure
6. distillationThe residual oil was distilled in vacuo

ORDレコード

ord-0be17192d99640d8918a901b6d87f90d

出典データセット

uspto-grants-1997_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05593983