5-Chloro-4-methoxy-2-nitroaniline → HCID 22573123、化合物

HRID 23353ノート

反応式

HRID 23353 の反応式
[Cl:1][C:2]1[C:3]([O:12][CH3:13])=[CH:4][C:5]([N+:9]([O-])=O)=[C:6]([NH2:8])[CH:7]=1>[Pd].CCOC(C)=O>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([NH2:8])[C:5]([NH2:9])=[CH:4][C:3]=1[O:12][CH3:13]

参加物

4

反応物 1

HCID 101043255-Chloro-4-methoxy-2-nitroaniline

生成物 1

HCID 22573123HCID 22573123、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of EtOAc (25 mL) and 5-chloro-4-methoxy-2-nitro-phenylamine (1.6 g, 7.9 mmol) under argon is added 5% Pd/C (0.5 g). The reaction mixture is hydrogenated at 50 psi for 1 hour. The mixture is filtered under N2 through Celite into a solution of 1 N HCl/Et2O in EtOAc, and the pad is washed with additional EtOAc. The resulting precipitate is filtered off to provide a white solid.

後処理

  1. filtrationThe mixture is filtered under N2 through Celite into a solution of 1 N HCl/Et2O in EtOAc
  2. washthe pad is washed with additional EtOAc
  3. filtrationThe resulting precipitate is filtered off
  4. customto provide a white solid

出典と根拠

ORDレコード
ord-cedb8daf16d44dbbb36deaf07cc42d30
出典データセット
uspto-grants-2005_02
特許番号
US06852712B2

反応ノート

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