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Potassium Carbonate → (R*,S*)-6-[5-(3-Chlorophenyl)-2-oxo-3-oxazolidinyl]-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-2,2-dicarboxylic acid diethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Propanedioic acid, 2,2-dibromo-, 1,3-diethyl ester | HCID 69427 | — |
| 反応物 | 5-(3-Chlorophenyl)-3-(1,2,3,4-tetrahydro-6,7-dihydroxynaphthalen-2-yl)-2-oxazolidinone | HCID 23358138 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | (R*,S*)-6-[5-(3-Chlorophenyl)-2-oxo-3-oxazolidinyl]-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-2,2-dicarboxylic acid diethyl ester | HCID 67619602 | 54.9% |
反応手順
A mixture of 0.90 g of the above catechol derivative, 0.836 g of diethyl dibromomalonate and 1.8 g of powdered anhydrous potassium carbonate in 15 ml of acetone is stirred at room temperature for 18 hours. The reaction mixture is filtered and concentrated in vacuo to give 0.708 g of a mixture of diastereomers as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05594027 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-fc06d8aa44f343808aff8578f99d8340 |
| 出典メモ | uspto-grants-1997_01 |