2-nitrobenzyl-N,N-dimethylsulfonamide → 2-aminobenzyl-N,N-dimethylsulfonamide
反応式
[N+:1]([C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[CH2:6][S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8])([O-])=O>[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[CH2:6][S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8]参加物
3
実験手順
The 2-nitrobenzyl-N,N-dimethylsulfonamide (0.825 g, 3.377 mmole) of Step 1 was dissolved/suspended in alcohol in a Parr hydrogenation bottle. Palladium on charcoal (90 mg, 10% Pd) was added and the mixture was placed under an atmosphere of hydrogen at 45 psi in a Parr shaker. After shaking overnight, the mixture was filtered through Celite and evaporated to dryness to afford 0.693 g pure 2-aminobenzyl-N,N-dimethylsulfonamide (96% yield).
後処理
- filtrationthe mixture was filtered through Celite
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-17bcca45b1f247b4b8c6e40e7e9f9671
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06852726B2
反応ノート
読み込み中…