Sodium Hydroxide → 3-(2-Bromophenyl)propionic acid

HRID 234076

反応式

HRID 234076 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([O:12]C)=[O:11].[OH-].[Na+]>C(O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([OH:12])=[O:11]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 15712815Methyl 3-(2-bromophenyl)propanoate

生成物 1

HCID 3160103-(2-Bromophenyl)propionic acid収率 96.1%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of methyl 3-(2-bromophenyl)propionate (35.77 g) in ethanol (80.7 ml) was added at room temperature dropwise a solution of sodium hydroxide (11.77 g) in water (40 ml). After the reaction mixture was stirred under reflux for 2.5 hrs. and left standing for cooling, methanol was removed by distillation under reduced pressure, the residue was poured into ice-hydrochloric acid and stirred for 20 minutes. Crystalline precipitates were filtered, washed well with water, dried under reduced pressure to give the title compound (32.4 g).

後処理

  1. temperatureunder reflux for 2.5 hrs
  2. waitand left standing
  3. temperaturefor cooling
  4. custommethanol was removed by distillation under reduced pressure
  5. additionthe residue was poured into ice-hydrochloric acid
  6. stirringstirred for 20 minutes
  7. customCrystalline precipitates
  8. filtrationwere filtered
  9. washwashed well with water
  10. customdried under reduced pressure

出典と根拠

ORDレコード
ord-aa64c040a29d4ca19be381a75352ec36
出典データセット
uspto-grants-1997_01
特許番号
US05594081

関連ノート

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