Ethanol → Ethyl ester of lactic acid glycolic acid

9 g of a lactic acid/glycolic acid copolymer having a weight-average molecular weight of about 7,500 (lactic acid/glycolic acid=75/25 (mol %)) (Wako Pure Chemical Industries, Ltd.) was dissolved in a mixed solvent consisting of 20 ml of dichloromethane and 20 ml of ethanol. While thus obtained solution was cooled and stirred, 0.45 ml of triethyl amine, 0.29 ml of ethyl chloroformate and 0.36 g of N,N-dimethylaminopyridine were added. After the resulting mixture was stirred for another 2 hours, 50 ml of dichloromethane and 50 ml of water were added and then dichloromethane phase was separated. The dichloromethane phase was washed 2 times with 50 ml of 10% ethanol-water, and then dried with magnesium sulfate. After magnesium sulfate was separated by filtration, the mixture was concentrated to dryness under reduced pressure to yield 7.7 g of the ethyl ester of lactic acid/glycolic acid copolymer.

1. dissolutionwas dissolved in a mixed solvent
2. temperatureWhile thus obtained solution was cooled
3. stirringAfter the resulting mixture was stirred for another 2 hours
4. customdichloromethane phase was separated
5. washThe dichloromethane phase was washed 2 times with 50 ml of 10% ethanol-water
6. dry with materialdried with magnesium sulfate
7. customAfter magnesium sulfate was separated by filtration
8. concentrationthe mixture was concentrated to dryness under reduced pressure

ORDレコード

ord-38b6023ee63b4506908dd3ebfbe2100e

出典データセット

uspto-grants-1997_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05594091