Kojic Acid → 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one

HRID 234149

反応式

HRID 234149 の反応式
[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[CH2:9][OH:10].C(=O)([O-])[O-].[K+].[K+].[CH2:17](Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CN(C=O)C>[CH2:17]([O:8][C:5]1[C:6](=[O:7])[CH:1]=[C:2]([CH2:9][OH:10])[O:3][CH:4]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

5

反応物 3

HCID 3840Kojic AcidHCID 7503Benzyl ChlorideHCID 11430Potassium Carbonate

生成物 1

HCID 9015985-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one収率 75.6%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To the solution of kojic acid (28 g) in DMF (200 ml) was added potassium carbonate (32 g), and the mixture was stirred at room temperature for 30 minutes. After benzyl chloride (25 g) was added, the mixture was further stirred for 60 minutes. The solvent was evaporated. The residue was then extracted with ethyl acetate, washed with water and dried. After the solvent was evaporated, the residue was crystallized from ethyl acetate to give 5-benzyloxy-2-hydroxymethyl-4-oxo-4H-pyran (34.6 g).

後処理

  1. stirringthe mixture was further stirred for 60 minutes
  2. customThe solvent was evaporated
  3. extractionThe residue was then extracted with ethyl acetate
  4. washwashed with water
  5. customdried
  6. customAfter the solvent was evaporated
  7. customthe residue was crystallized from ethyl acetate

出典と根拠

ORDレコード
ord-e50df54098a84e479a9dd6dc06e6abaf
出典データセット
uspto-grants-1997_01
特許番号
US05594004

関連ノート

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