Tetrahydrofuran → Tert-butyl 4-hydroxy-4-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate
反応式
[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[CH3:1][c:2]1[cH:3][c:4]([NH:13][c:14]2[n:15][cH:16][cH:17][c:18]([C:20]([F:21])([F:22])[F:23])[n:19]2)[cH:5][c:6](-[c:8]2[cH:9][n:10][cH:11][s:12]2)[cH:7]1.[CH3:25][CH:26]([N-:27][CH:28]([CH3:29])[CH3:30])[CH3:31].[Li+:24].[O:32]=[C:33]1[CH2:34][CH2:35][N:36]([C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])[CH2:37][CH2:38]1>>[CH3:1][c:2]1[cH:3][c:4]([NH:13][c:14]2[n:15][cH:16][cH:17][c:18]([C:20]([F:21])([F:22])[F:23])[n:19]2)[cH:5][c:6](-[c:8]2[cH:9][n:10][c:11]([C:33]3([OH:32])[CH2:34][CH2:35][N:36]([C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])[CH2:37][CH2:38]3)[s:12]2)[cH:7]1
