Water → HCID 178418251、化合物

HRID 2343

反応式

HRID 2343 の反応式
[CH2:1]([C:5]1[NH:6][C:7]([CH2:11][OH:12])=[C:8]([Cl:10])[N:9]=1)[CH2:2][CH2:3][CH3:4].O>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]([C:5]1[NH:6][C:7]([CH:11]=[O:12])=[C:8]([Cl:10])[N:9]=1)[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 2

HCID 962WaterHCID 27356622-Butyl-4-chloro-5-(hydroxymethyl)imidazole

生成物 1

HCID 178418251HCID 178418251、化合物収率 86.3%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A stirred mixture of 2-n-butyl-4-chloro-5-hydroxymethylimidazole (15.00 g, 0.0795 mol) and activated manganese dioxide (40.00 g) in 600 ml of methylene chloride was refluxed for 24 h using a water separator. The mixture was filtered hot through a Celite® pad. The Celite® pad was washed several times with hot methylene chloride. The washings were combined with the filtrate and concentrated in vacuo to give 12.81 g (86%) of the aldehyde as a white solid; mp 97°-98° C.

後処理

  1. temperaturewas refluxed for 24 h
  2. filtrationThe mixture was filtered hot through a Celite® pad
  3. washThe Celite® pad was washed several times with hot methylene chloride
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0fdf59899d7d46d0ae418ee316a592b9
出典データセット
uspto-grants-1998_03
特許番号
US05728842

関連ノート

読み込み中…