Trityl chloride → 4-Iodo-1-(triphenylmethyl)-1H-pyrazole

HRID 23446

反応式

HRID 23446 の反応式
[I:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.[C:7]1([C:13](Cl)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C>CN(C=O)C>[C:13]([N:4]1[CH:3]=[C:2]([I:1])[CH:6]=[N:5]1)([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

参加物

5

反応物 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 770224-Iodopyrazole

生成物 1

HCID 153244794-Iodo-1-(triphenylmethyl)-1H-pyrazole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The title compound was prepared by combining 4-iodopyrazole (10 g, 52 mmol), triphenylmethyl chloride (14.4 g, 51.6 mmol), triethylamine (NEt3) (7.2 mL, 52 mmol), and DMF (80 mL). After stirring overnight, the mixture was poured onto ice water. The precipitated solid was collected and recrystallized to give the title compound as a solid, mp 193-194° C.

後処理

  1. customThe title compound was prepared
  2. additionthe mixture was poured onto ice water
  3. customThe precipitated solid was collected
  4. customrecrystallized

出典と根拠

ORDレコード
ord-d3ef2a74458c4b448cd736d864cc3c8b
出典データセット
uspto-grants-2005_02
特許番号
US06852711B2

関連ノート

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