2-Methyl-4-methoxyaniline → N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(4-methoxy-2-methylphenyl)aminocarbonyl]thiophene-3-sulfonamide

HRID 234470

反応式

[Cl:1][C:2]1[C:3]([CH3:25])=[N:4][O:5][C:6]=1[NH:7][S:8]([C:11]1[CH:15]=[CH:14][S:13][C:12]=1[C:16]([NH:18][C:19]1SC(C)=NN=1)=[O:17])(=[O:10])=[O:9].[CH3:26][O:27][C:28]1[CH:34]=[CH:33][C:31](N)=[C:30](C)[CH:29]=1>N1C=CC=CC=1>[Cl:1][C:2]1[C:3]([CH3:25])=[N:4][O:5][C:6]=1[NH:7][S:8]([C:11]1[CH:15]=[CH:14][S:13][C:12]=1[C:16]([NH:18][C:19]1[CH:33]=[CH:34][C:28]([O:27][CH3:26])=[CH:29][C:30]=1[CH3:31])=[O:17])(=[O:9])=[O:10]

参加物

実験手順

N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(4-methoxy-2-methylphenyl)aminocarbonyl]thiophene-3-sulfonamide was prepared by the method set forth for N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(2-methyl-1,3,4-thiadiazol-5-yl)aminocarbonyl]thiophene-3-sulfonamide (EXAMPLE 150), except that 4-methoxy-2-methylaniline was used instead of 2-amino-5-methyl-1,3,4-thiadiazole and that pyridine was not used. The title compound was obtained via HPLC purification as a dull yellow powder (66% yield, m.p. 58°-62° C.).

後処理

customN-(4-chloro-3-methyl-5-isoxazolyl)-2-[(4-methoxy-2-methylphenyl)aminocarbonyl]thiophene-3-sulfonamide was prepared by the method

出典と根拠

ORDレコード: ord-2858442a5b47413790fae53e184b0f05
出典データセット: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05594021

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

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