2-Methoxy-4-nitrobenzenesulfonyl chloride → 3-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydro-1-(2-methoxy-4-nitrobenzenesulfonyl)indol-2-one

HRID 234522

反応式

HRID 234522 の反応式
[NH2:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH2:12][CH3:13])[CH:9]=2)[NH:4][C:3]1=[O:14].[CH3:22][O:23][C:24]1[CH:29]=[C:28]([N+:30]([O-:32])=[O:31])[CH:27]=[CH:26][C:25]=1[S:33](Cl)(=[O:35])=[O:34]>>[NH2:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH2:12][CH3:13])[CH:9]=2)[N:4]([S:33]([C:25]2[CH:26]=[CH:27][C:28]([N+:30]([O-:32])=[O:31])=[CH:29][C:24]=2[O:23][CH3:22])(=[O:34])=[O:35])[C:3]1=[O:14]

参加物

3

反応物 2

HCID 3094582-Methoxy-4-nitrobenzenesulfonyl chlorideHCID 190763873-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydroindol-2-one

生成物 1

HCID 190764113-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydro-1-(2-methoxy-4-nitrobenzenesulfonyl)indol-2-one

実験手順

This compound is prepared according to the procedure described in EXAMPLE 16 from 3-amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydroindol-2-one and 2-methoxy-4-nitrobenzenesulfonyl chloride. Crystallization from a DCM/iso ether mixture gives the expected product, which crystallizes with 0.25 mol of iso ether. M.p.=129°-132° C.

後処理

  1. customThis compound is prepared
  2. customCrystallization from a DCM/iso ether mixture

出典と根拠

ORDレコード
ord-74faeb8c800f43248f65605ae7ef33e5
出典データセット
uspto-grants-1997_01
特許番号
US05594023

関連ノート

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