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2-Methoxy-4-nitrobenzenesulfonyl chloride → 3-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydro-1-(2-methoxy-4-nitrobenzenesulfonyl)indol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxy-4-nitrobenzenesulfonyl chloride | HCID 309458 | — |
| 反応物 | 3-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydroindol-2-one | HCID 19076387 | — |
| 生成物 | 3-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydro-1-(2-methoxy-4-nitrobenzenesulfonyl)indol-2-one | HCID 19076411 | — |
反応手順
This compound is prepared according to the procedure described in EXAMPLE 16 from 3-amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydroindol-2-one and 2-methoxy-4-nitrobenzenesulfonyl chloride. Crystallization from a DCM/iso ether mixture gives the expected product, which crystallizes with 0.25 mol of iso ether. M.p.=129°-132° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05594023 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-74faeb8c800f43248f65605ae7ef33e5 |
| 出典メモ | uspto-grants-1997_01 |