1-Bromo-4-tert-butyl-2-nitrobenzene → 3-tert-Butylaniline

HRID 23458

反応式

HRID 23458 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:11])([CH3:10])[CH3:9])=[CH:4][C:3]=1[N+:12]([O-])=O.[H][H]>[Pd].CO>[C:8]([C:5]1[CH:4]=[C:3]([NH2:12])[CH:2]=[CH:7][CH:6]=1)([CH3:11])([CH3:9])[CH3:10]

参加物

5

反応物 2

HCID 112539061-Bromo-4-tert-butyl-2-nitrobenzeneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 793343-tert-Butylaniline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

1-Bromo-4-tert-butyl-2-nitro-benzene (18 g) was reduced as described in General Method 3 using 10% palladium on charcoal (1 g) and MeOH (100 mL) in a hydrogen atmosphere (50 psi). The catalyst was filtered, and the solvents were evaporated. The residue was taken in EtOAc (100 mL) and washed with saturated sodium bicarbonate solution and H2O. The solution was dried and concentrated. The residue was purified by flash chromatography to give 3-tert-butyl-phenylamine. MS (APCI): 150 (M+H).

後処理

  1. filtrationThe catalyst was filtered
  2. customthe solvents were evaporated
  3. washwashed with saturated sodium bicarbonate solution and H2O
  4. customThe solution was dried
  5. concentrationconcentrated
  6. customThe residue was purified by flash chromatography

出典と根拠

ORDレコード
ord-d7f5f06869914232b71e686a20541302
出典データセット
uspto-grants-2005_02
特許番号
US06852711B2

関連ノート

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