Dichloromethane → 2,6-difluoro-N-{2-fluoro-3-[5-(2-methyl-4-pyrimidinyl)-2-(4-piperidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

反応式

[Cl:52][CH2:53][Cl:54].[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[c:14]([F:44])[c:15](-[c:19]3[n:20][c:21]([CH:31]4[CH2:32][CH2:33][N:34]([C:37]([O:38][C:39]([CH3:40])([CH3:41])[CH3:42])=[O:43])[CH2:35][CH2:36]4)[s:22][c:23]3-[c:24]3[n:25][c:26]([CH3:30])[n:27][cH:28][cH:29]3)[cH:16][cH:17][cH:18]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1.[F:45][C:46]([F:47])([F:48])[C:49]([OH:50])=[O:51]>>[F:1][c:2]1[c:3]([S:9](=[O:10])(=[O:11])[NH:12][c:13]2[c:14]([F:44])[c:15](-[c:19]3[n:20][c:21]([CH:31]4[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]4)[s:22][c:23]3-[c:24]3[n:25][c:26]([CH3:30])[n:27][cH:28][cH:29]3)[cH:16][cH:17][cH:18]2)[c:4]([F:8])[cH:5][cH:6][cH:7]1