3',5'-DIACETYLTHYMIDINE → Thymidine

HRID 234777ノート

反応式

HRID 234777 の反応式
C([O:4][C@@H:5]1[C@@H:9]([CH2:10][O:11]C(=O)C)[O:8][C@@H:7]([N:15]2[CH:23]=[C:21]([CH3:22])[C:19](=[O:20])[NH:18][C:16]2=[O:17])[CH2:6]1)(=O)C.[Na]>CO>[CH3:22][C:21]1[C:19](=[O:20])[NH:18][C:16](=[O:17])[N:15]([C@@H:7]2[O:8][C@H:9]([CH2:10][OH:11])[C@@H:5]([OH:4])[CH2:6]2)[CH:23]=1

参加物

4

反応物 2

HCID 27243483',5'-DIACETYLTHYMIDINEHCID 5360545Sodium

生成物 1

HCID 5789Thymidine収率 80%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Crude 3',5'-di-O-acetylthymidine was dissolved in 20 ml methanol, and 0.075 gm sodium was added. After 8 hrs the reaction was quenched with Amberlite IR 120 resin, filtered and concentrated to yield beta-thymidine (2.4 gm, 80%). m.p. 181°-183° C.

後処理

  1. customAfter 8 hrs the reaction was quenched with Amberlite IR 120 resin
  2. filtrationfiltered
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-4cc11fb97f7d47c7a671f334bcbab49a
出典データセット
uspto-grants-1997_01
特許番号
US05596087

反応ノート

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