Thionyl Chloride → 3,5-Dichlorobenzyl chloride

HRID 234935

反応式

HRID 234935 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5]O.S(Cl)([Cl:13])=O>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH2:5][Cl:13]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 432363,5-Dichlorobenzylic alcohol

生成物 1

HCID 1378803,5-Dichlorobenzyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 3,5-dichlorobenzyl alcohol (Aldrich, 25 g) , thionyl chloride (100 ml) and DMF (0.5 ml) was stirred and refluxed for 4 hours. After cooling the mixture was concentrated in vacuo, the residue was taken up in ether, washed with saturated aqueous NaHCO3 and brine, dried (MgSO4) and concentrated in vacuo to give 3,5-dichlorobenzyl chloride as a light yellow solid, which was used without further purification, 28 g, mp. 32°-36° C.

後処理

  1. temperaturerefluxed for 4 hours
  2. temperatureAfter cooling the mixture
  3. concentrationwas concentrated in vacuo
  4. washwashed with saturated aqueous NaHCO3 and brine
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0e68d73215e841639b2447213a833f42
出典データセット
uspto-grants-1997_01
特許番号
US05597827

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