Dicyclohexylcarbodiimide → HCID 19848167、化合物

To a stirred solution of 1,2-bis(4-fluorophenyl)-2-propylamine (8.47 g, 0.034 mol) in 200 ml of chloroform under nitrogen, was added N-CBZ-glycylglycine (9.13 g, 0.034 mol) and then a solution of dicyclohexylcarbodiimide (7.43 g, 0.036 mol) in 100 ml of chloroform and the mixture stirred for 72 hours. The precipitated solid was removed by filtration and the solvent evaporated. The residue was treated with ethylacetate (125 ml), filtered, an additional 250 ml of ethylacetate added and then washed with cold 1% HCl (150 ml), brine (200 ml), dried and the solvent evaporated. The residue was dissolved in 400 ml of methanol and 35 ml of 10% HCl and hydrogenated at 40 psi in a Parr apparatus over 3.0 g of 5% Pd/c catalyst for 3 hours. The catalyst was removed by filtration, solvent evaporated and the residue dissolved in water (300 ml) and chloroform (300 ml), basified to pH 11 with 50% NaOH, shaken and separated. The aqueous phase was extracted with chloroform (3×150 ml), and the combined organic phases were washed with water (2×200 ml), dried, and evaporated to a pale yellow oil. This oil was crystallized from cyclohexane (150 ml) and ethanol (5 ml); the solid obtained was recrystallized from hexane (150 ml) and ethanol (10 ml), and vacuum dried at 83° C. for 96 hours to give 3.64 g of 2-glycinamido-N-[1,2-bis(4-fluorophenyl)-1-methylethyl]acetamide, mp. 139°-140° C.

1. customThe precipitated solid was removed by filtration
2. customthe solvent evaporated
3. additionThe residue was treated with ethylacetate (125 ml)
4. filtrationfiltered
5. additionan additional 250 ml of ethylacetate added
6. washwashed with cold 1% HCl (150 ml), brine (200 ml)
7. customdried
8. customthe solvent evaporated
9. dissolutionThe residue was dissolved in 400 ml of methanol
10. customThe catalyst was removed by filtration, solvent
11. customevaporated
12. dissolutionthe residue dissolved in water (300 ml)
13. customseparated
14. extractionThe aqueous phase was extracted with chloroform (3×150 ml)
15. washthe combined organic phases were washed with water (2×200 ml)
16. customdried
17. customevaporated to a pale yellow oil
18. customThis oil was crystallized from cyclohexane (150 ml) and ethanol (5 ml)
19. customthe solid obtained
20. customwas recrystallized from hexane (150 ml) and ethanol (10 ml), and vacuum
21. customdried at 83° C. for 96 hours

ORDレコード

ord-8b58b168657b455881ae5007cfd332ac

出典データセット

uspto-grants-1989_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04871872